Foxd1 is required for proper formation of the optic chiasm
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چکیده
منابع مشابه
Foxd1 is required for proper formation of the optic chiasm.
In animals with binocular vision, retinal ganglion cell (RGC) axons from each eye sort in the developing ventral diencephalon to project to ipsi- or contralateral targets, thereby forming the optic chiasm. Ipsilaterally projecting axons arise from the ventrotemporal (VT) retina and contralaterally projecting axons primarily from the other retinal quadrants. The winged helix transcription factor...
متن کاملGenerating X Formation of the Optic Chiasm
At the optic chiasm, axons from either eye meet and decide whether to cross contralaterally or turn back ipsilaterally. Here, the guidance ligand Slit and its receptor Robo control not whether axons cross (as in other midline decisions), but where the chiasm forms. Whether axons cross is instead controlled by the transcription factor Zic2 and the guidance receptor EphB1, as shown by two papers ...
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Primary malignant gliomas of the optic nerve and chiasm are rare, and are usually rapidly fatal in adults. We report a 48-year-old woman with a glioblastoma multiforme arising from the optic chiasm. Following radiotherapy, our patient survived nearly 14 months, which is the longest survival reported in patients with this diagnosis. There have only been four other reports of glioblastoma multifo...
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Eight verified lesions of the optic chiasm were examined on 0.5 T magnetic resonance (MR) and GE 9800, 8800 computed tomographic (CT) scanners. Enlargement of the optic chiasm was demonstrated in all cases. There was some change of MR signal compared with brain in all but one case, which had no resemblance to contrast enhancement on CT scans. The signal was specific for hematoma in one case. Ab...
متن کاملMetalloproteinase Adamts16 Is Required for Proper Closure of the Optic Fissure.
Purpose Coloboma is a sight-threatening congenital eye disease caused by a failure in optic fissure (OF) closure. The aim of this study was to investigate the role of Adamts16, a metalloproteinase, in OF closure. Methods RNA in situ hybridization was used to examine the expression of Adamts16 in developing mouse and zebrafish eyes. Morpholino knockdowns were performed to study adamts16 functi...
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ژورنال
عنوان ژورنال: Development
سال: 2004
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.01431